Right Drug, Right Dose Through Personalized Medicine
Doctor’s generally prescribe medications based upon symptoms or because of the results of a physical. However, according to FDA.gov more than 75% of people have genetic variations that affect how they respond to the most commonly prescribed medications.
Now, with a DNA assessment called Pharmacogenomics, your doctor can reduce trial and error, and prescribe the most effective medicine and dosage with the least amount of risk and unwanted side effects right from the start.
Pharmacogenomics is a science that combines pharmacology, (the science of drugs) and genomics, (the study of genes and their functions). This can determine how our genetic variations affect our individual response to a medication through gene to drug, and drug to drug reactions.
For example, on an individualized basis, pharmacogenomic tests can identify the most effective blood-thinner or anti-depressant and their dosages, or if you will in fact metabolize codeine to morphine, which must happen for it to be an effective pain reliever.
Additionally, the results may not only call for a change in your current medications, but they will also be part of your medical records and could be a “road map” for your future medications.
If you are being prescribed stimulants, antidepressants, antipsychotics, mood stabilizers, or antianxiety medications:
The personalized results of a your pharmacogenomic test can provide additional information to assist your physician in determining the most effective medication, dosage, and medical protocols specifically for you.
Genotyping for CYP2D6 and CYP2C19 variations are potentially useful clinical tool to help mental health professionals prescribe psychiatric medications for their patients. CYP2D6 is involved in the metabolism of more than 70 drugs, including many antidepressants and antipsychotics. Based on the CYP2D6 DNA testing for antidepressants, a patient’s doses can be adjusted to minimize drug toxicity.
Is involved in the metabolism of a wide range of anti-depressants and benzodiazepines. Cytochrome P450 testing can assist in the determination of an individual's required dosage of identified drugs that are metabolized by CYP2D6 and CYP2C19.
Is primarily responsible for clozapine metabolism. The genetic studies of clozapine drug response are supported by the identification of multiple functional variants in CYP1A2, with well-defined effects on clozapine metabolism. CYP1A2 genetic lab testing can assist in determining the correct doses of this medication.
Plays an important role also in psycho- pharmacotherapy as it contributes to the biotransformation of various antidepressants, antipsychotics, benzodiazepines.
The D2 dopamine receptor encoded from DRD2 is the primary target of most antipsychotic medications. The ankyrin repeat and kinase domain containing 1 gene (ANKK1) is located 10 kb from DRD2 and has been associated with tardive dyskinesia (TD). DRD2 genetic testing can assist in determining dosing for these medications.
A patient’s genetic profile can help define the appropriateness and dosage of many prescribed psychotropic drugs including:
Therapeutic Class Name of Drug
Antidementia Donepezil (Aricept®)
Smoking Cessation Agents
If you are being prescribed Cardiovascular medications:
Coronary artery disease medications are influenced by multiple genes that interact in complicated ways. The personalized results of your pharmacogenomic test can provide additional information to assist your physician in determining the most effective medication and dosage and medical protocols specifically for you.
Beta Blocker metabolism (carvedilol, metoprolol, yohimbine, timolol); antiarrhythmics (flecainide, mexiletine, propafenone). It metabolizes 25% of all prescribed drugs.
Is the most abundantly expressed enzyme in the human liver, accounting for the metabolism of approximately 15-20% of prescribed medications such as the anticoagulant Warfarin, the antihypertensive drug losartan, the diuretic Torsemide, and nonsteroidal anti-inflammatory drugs, (NSAIDs), such as ibuprofen, Diclofenac, Piroxicam, Tenoxicam.
VKORC1 gene testing is done for those currently taking or going to take blood thinners and this gene has been connected to Warfarin response. VKORC1 genetic lab testing will help physicians understand potential adverse reactions and appropriate doses.
Factor V Leiden
Inherited Thrombophilia. Factor V Leiden mutation is the greatest common inherited predisposition for hypercoagulability. People with Factor V Leiden mutation with thrombophilia have higher than average risk of developing a deep venosus thrombosis (DVT).
Factor 2 / Factor II
Prothrombin deficiency, thus creating the potential of a hypercoagulable state, a condition that causes your blood to clot more easily than normal.