Cardiovascular Disease

One person dies every 37 seconds in the United States from cardiovascular disease.  About 647,000 Americans die from heart disease each year—that's 1 in every 4 deaths. 

 

Why Take a Cardiovascular Hereditary DNA Assessment?

One person dies every 37 seconds in the United States from cardiovascular disease.
About 647,000 Americans die from heart disease each year—that's 1 in every 4 deaths. 

 

It’s not just a man’s disease. While 1 in 31 American women dies from breast cancer each year, heart disease is the leading cause of death for women in the United States according to the CDC, and fewer women than men survive their first heart attack according to AHA.

 

Many cardiac disorders can be inherited, including:

• arrhythmias,

• congenital heart disease,
• cardiomyopathy,

• and high blood cholesterol.

 

Coronary artery disease leading to heart attack, stroke, and heart failure can run in families, indicating inherited genetic risk factors inherited from your mother and father. If you know about your risk ahead of time, you may be able to get ahead of the problem, before it causes symptoms or becomes dangerous. 

 

Our Cardio Dx Hereditary DNA assessment examines 32 well-established cardiovascular disease genes for the purpose of identifying likely pathogenic variants (mutations) associated with hereditary cardiovascular conditions. When such a variant (or mutation) is inherited, development of symptoms is more likely.  Cardiovascular diseases tested for on this panel include, but are not limited to cardiomyopathies, arrhythmias, vascular & connective tissue diseases, and congenital heart. disease. This panel is designed for individuals with a personal and/or family history of. cardiovascular disease to help establish or confirm a diagnosis, assess risks, or guide. management.

 

Each of the conditions tested for is considered clinically actionable. Potential treatmentmoptions for some of our tested conditions include frequent screenings, medication, enzymenreplacement therapy, implantable devices, surgery, and lifestyle recommendations.  The complete assessment provides results that are very comprehensive which will allow your healthcare provider to determine a protocol, if required, that can mitigate or even prevent. certain symptoms from happening. On page 2 we have listed some of the more common cardiovascular diseases that may be hereditary.


Some Common Cardiovascular Diseases that May be Hereditary.

 

Cardiomyopathy- Every day your heart pumps the equivalent of 2,000 gallons of blood. throughout your body and creates enough energy to drive a truck 20 miles!  It’s no wonder the heart is the most important muscle in the body. But certain conditions can affect how well it. works. Weakening or disease of your heart muscle is called cardiomyopathy and occurs in the. lower chambers of the heart called ventricular cardiomyopathy.
 

Arrhythmias- A cardiac arrhythmia is any abnormal heart rate or rhythm. Tachycardia is a. common type of arrhythmia (abnormal heartbeat) that occurs when the heart beats too fast while. at rest. An adult's heart usually beats between 60 and 100 times per minute at rest. Tachycardia is. a heart rate over 100 beats per minute. In some cases, tachycardia doesn't cause any complications. In other cases, however, untreated tachycardia can cause serious complications,  such as stroke, heart failure, or death.

 

Congenital Heart Disease Congenital heart disease or defect is a problem with the structure of. the heart. It is present at birth. Congenital heart defects are the most common type of birth defect.  The defects can involve the walls of the heart, the valves of the heart, and the arteries and veins. near the heart. They can disrupt the normal flow of blood through the heart. The blood flow can. slow down, go in the wrong direction or to the wrong place, or be blocked completely.
 

Vascular and Connective tissues Disease significantly affects the aorta which is exposed to. high shear stress, or pressure from the constant flow of blood. The aorta is a very well designed. pipe that must convert chaotic flow into an organized stream. Two sites of chaos exist in the  aorta. The first is at the aortic root, where blood shoots out of the heart, and if the strength layer of the aorta is dysfunctional, the stress might internally break the aorta (a type A Dissection).  The second site of chaos is at the end of the aortic arch, where blood must loop around and head. downwards to supply blood to the abdomen and legs. The aorta  may tear at this juncture as well. a so-called type B Dissection). Many patients do not know that they may have this possibly inherited condition. Type A dissection is the more dangerous form, but chances of survival are. significantly improved with early detection and management.

 
Some Cardio Genes We Assess
 
Conditions Suggesting a Cardiovascular Hereditary DNA Assessment

1. Breathlessness even at rest or especially with physical exertion
2. Shortness of breath or trouble breathing
3. Swelling of the legs, ankles and feet
4. Swelling in the abdomen and veins in the neck
5. Undiagnosed dry hacking cough or wheezing
6. Chronic fatigue
7. Heartbeat that feel rapid or irregular
8. Chest discomfort, pressure, pounding or fluttering
9. Dizziness, lightheadedness and fainting
10. Chest pain, especially after physical exertion or heavy meals
11. Long-term high blood pressure
12. Use of cocaine, amphetamines or anabolic steroids
13. Metabolic disorders, such as obesity, thyroid disease or diabetes
14. Nutritional deficiencies of essential vitamins or minerals, such as thiamin
(vitamin B-1)
15. Heart attack
16. Heart valve problems
17. Any diagnosed cardiovascular disease
18. Stent

 

Any one of the conditions 1 through 15 suggest a patient and their family can benefit from a cardiovascular DNA assessment, especially if the patient has more than one condition, or a bloodline family member was diagnosed with cardiovascular disease.

 

Conditions 16 through 18 strongly suggests a patient and their family can benefit from a cardiovascular DNA assessment.

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